Arquivo da tag: estudos sociais da ciência e da tecnologia

Adam Tooze: Bruno Latour and the philosophy of life (New Statesman)

newstatesman.com

For the late French intellectual in an age of ecological crisis it was crucial to understand ourselves as rooted beings.

Adam Tooze

17 October 2022


As Bruno Latour confided to Le Monde earlier this year in one of his final interviews, philosophy was his great intellectual love. But across his long and immensely fertile intellectual life, Latour pursued that love by way of practically every other form of knowledge and pursuit – sociology, anthropology, science, history, environmentalism, political theory, the visual arts, theatre and fiction. In this way he was, above all, a philosopher of life in the comprehensive German sense of Lebensphilosophie.

Lebensphilosophie, whose leading exponents included figures such as Friedrich Nietzsche and Martin Heidegger, enjoyed its intellectual heyday between the 1870s and the 1930s. It was a project that sought to make sense of the dramatic development of modern science and the way it invaded every facet of life. In the process, it relentlessly questioned distinctions between the subject and knowledge and the foundations of metaphysics. It spilled over into the sociology of a Max Weber or the Marxism of a György Lukács. In France, writer-thinkers such as Charles Péguy or Henri Bergson might be counted as advocates of the new philosophy. Their heirs were the existentialists of the 1940s and 1950s. In the Anglophone world, one might think of the American pragmatists, William James and John Dewey, the Bloomsbury group and John Maynard Keynes.

A century later, the project of a “philosophy of life” acquired new urgency for Latour in an age of ecological crisis when it became crucial to understand ourselves not as free-floating knowing and producing subjects, but as rooted, or “landed”, beings living alongside others with all the limits, entanglements and potentials that entailed.

The heretical positions on the status of scientific knowledge for which Latour became notorious for some, are best understood as attempts to place knowledge and truth claims back in the midst of life. In a 2004 essay entitled “How to Talk About the Body?” he imagined a dialogue between a knowing subject as imagined by a naive epistemology and a Latourian subject:

“‘Ah’, sighs the traditional subject [as imagined by simplistic epistemologies], ‘if only I could extract myself from this narrow-minded body and roam through the cosmos, unfettered by any instrument, I would see the world as it is, without words, without models, without controversies, silent and contemplative’; ‘Really?’ replies the articulated body [the Latourian body which recognises its relationship to the world and knowledge about it as active and relational?] with some benign surprise, ‘why do you wish to be dead? For myself, I want to be alive and thus I want more words, more controversies, more artificial settings, more instruments, so as to become sensitive to even more differences. My kingdom for a more embodied body!’”

The classical subject-object distinction traps the knowing subject in a disembodied, unworldly position that is, in fact, tantamount to death. As Latour wrote in a brilliant passage in the same essay on the training of noses, the expert smell-testers who gauge perfume, or tea or wine: “A direct and unmediated access to the primary qualities of odours could only be detected by a bodiless nose.” But what kind of image of knowledge is this? “[T]he opposite of embodied is dead, not omniscient.”

For a Burgundian – Latour was born in 1947 into a storied family of wine négociant in Beaune – this was an obvious but profound truth. To really know something, the way a good Burgundian knows wine, means not to float above the world, but to be a porous part of it, inhaling, ingesting fermentation and the chemical elements of the terroir, the irreducibly specific terrain.

For Latour, claims to meaningful knowledge, including scientific knowledge, were generated not by simple rules and procedures that could be endlessly repeated with guaranteed results, but through immersion in the world and its particularities. This implied an existential engagement: “Knowing interestingly is always a risky business,” he wrote, “which has to be started from scratch for any new proposition at hand.” What made for generative scientific discovery was not the tautological reproduction of a state of affairs by a “true” statement, but the “fecundity, productivity, richness, originality” of good articulations. Distinctions between true and false were, more often than not, banal. Only anxious epistemologists and methodologists of science worried about those. What mattered to actual scientific practice was whether a claim was “boring”, “repetitive”, “redundant”, “inelegant”, “simply accurate”, “sterile”.

If Latour was a sceptic when it came to naive claims of “detached” scientific knowledge, this also applied doubly to naive sociologies of knowledge. Critical analyses of power, whether anti-capitalist, feminist or postcolonial, were productive and inspiring. But unless it was subject symmetrically to the same critique to which Latour subjected naive claims to scientific knowledge, social theory, even that which proclaimed itself to be critical theory, could all too easily become a snare. If the relationship of life and knowledge was the problem, then, you could not cut through that Gordian knot by invoking sociology to explain physics. What was sociology, after all, but a form of organised social knowledge? For better or for worse, all you were doing in such an exercise was multiplying the articulations from one scientific discipline to another and not necessarily in a helpful or illuminating direction.

In refusing the inherited authority of the 19th and early 20th-century canon of critical social science, Latour sought to create a form of knowledge more adequate to the late 20th and early 21st centuries. Latour thus belongs alongside Michel Foucault and Gilles Deleuze and Félix Guattari as one of the French thinkers who sought to escape the long shadow of Marxism, whether in its Hegelian (Sartre) or its anti-Hegelian (Althusser) varieties.

In place of an overly substantive notion of “the economy” or “society”, Latour proposed the looser conception of actor-networks. These are assemblages of tools, resources, researchers, means of registering concepts, and doing things that are not a priori defined in terms of a “mode of production” or a particular social order. Think of the lists of interconnected objects, systems and agents that have held our attention in the past few years: shipping containers, the flow of rainwater in Taiwan, giant freighters stuck sideways in the Suez Canal driven off course by unpredictable currents and side winds. Each of these supply chain crises has exposed actor-networks, of which we were previously oblivious. During such moments we are forced to ask: what is macro and what is micro? What is base and what is superstructure? These are Latourian questions.

One of the productive effects of seeing the world this way is that it becomes irresistibly obvious that all sorts of things have agency. This realisation is disturbing because it seems to downgrade the privilege of actual human existence and the social relations between people. But Latour’s point was never to diminish the human, but instead to emphasise the complex array of forces and agencies that are entailed in our modern lives. Our existence, Latour tried to show, depends not on the simple structures that we imagined modernity to consist of – markets, states and so on – but on the multiplication of what he calls hybrids, “supply chains” in the widest sense of the word.

Latour was not a class militant. But that does not mean that he did not have a cause. His lifelong campaign was for modernity to come to consciousness of itself, to stop taking its own simplifications at face value, to recognise the confusions and hybridity that it creates and endlessly feeds off. His mission was to persuade us, as the title of his most widely read book has it, that We Have Never Been Modern (1991). The confusion of a world in which lipid bubbles, aerosols and face masks have occupied our minds for years is what Latour wanted to prepare us for.

What Latour sought to expose was the pervasive animism that surrounds us in the form of hybrid actor-networks, whose force and significance we consistently deny. “Hybrids are everywhere,” he said, “but the question is how do you tame them, or do you explicitly recognise their strengths, which is part of the animist power of objects?” What Latour diagnosed is that modernity, as part of its productive logic, systematically denies this animation of the material world. “Modernism is the mode of life that finds the soul with which matter would be endowed, the animation, shocking.”

This repression of hybrid, animated material reality, is exposed in the often-racialised embarrassment of those who believe themselves modern when they encounter human civilisations that make no secret of their animist beliefs. It also accounts for the embarrassment triggered among true believers in modern science and its ideology by the revelations of the best histories of science, such as those by Simon Schaffer, to whom Latour owed a great debt. To Latour’s delight Schaffer showed how Isaac Newton, in the first instance, saw in gravity the manifestation of the power of angels.

The modernist impulse is to dismiss such ideas as hangovers of an earlier religious world-view and to relegate African art to the anthropology museum. But at the risk of provocation and scandal, Latour’s response was the opposite. Rather than finishing the purification of modernity and expunging angels and animism from our view of the forces that move the world, he urged that we should open our ontology to encompass the giant dark matter of hybrid concepts and real networks that actually sustain modern life.

From the 1990s onwards this made Latour one of the foremost thinkers in the ecological movement. And once again he reached for the most radical and encompassing animist notion with which to frame that commitment – the Gaia concept, which postulates the existence of a single overarching living being, encompassing global ecology. This is an eerie, supernatural, non-modern idea. But for Latour, if we settle for any more mundane description of the ecological crisis – if we fit the environment into pre-existing cost-benefit models as economists often do – we fail to recognise the radicalism of the forces that we have unleashed. We fail to understand the peril that we are in: that Gaia will lose patience and toss us, snarling, off her back.

Latour’s emphatic embrace of life, plenitude and articulation did not mean that he shrank from finitude or death. Rather the opposite. It is only from a thoroughly immanent view that you truly feel the weight of life lived towards its end, and the mysterious and awesome finality that is death. It is only from an embrace of life as emphatic as Latour’s, that you truly register the encroachment of deadening forces of the mind and the body. For Latour, life and death were intertwined by the effort of those left behind to make sense of death, by every means at their disposal, sometimes at very long distance.

In September 1976 the body of Ramesses II, the third pharaoh of the 19th Dynasty of Egypt, was flown to Paris. He was welcomed with the full military honours appropriate for a great ruler, and then his body was whisked to the laboratory to be subject to medical-forensic examination. For Latour this fantastic juxtaposition of the ancient and the modern was an irresistible provocation. The naive position was that the scientists discovered that Ramesses died of tuberculosis 3,000 years ago. He was also, a racially minded police forensic scientist claimed, most likely a redhead. For Latour, the question was more basic. How can we debate claims made self-confidently about a death that took place thousands of years ago? We were not there. There was no modern medical science then. When Ramesses ceased to live, TB was not even a “thing”. It was not until 1882 that Robert Koch in Berlin identified the bacillus. And even then, no one could have made any sensible claim about Ramesses. Making the naive, apparently matter-of-fact claim – that Ramesses died of TB in 1213 BC – in fact involves giant leaps of the imagination.

What we do know and can debate are what Latour would call “articulations”. We know that as a result of the intervention of the French president Valéry Giscard D’Estaing the Egyptian authorities were prevailed upon to allow the decaying mummy to be flown to Paris for preservation. We know that in Paris, what was left of the body was enrolled in modern technoscientific systems and testing procedures leading us to venture hypotheses about the cause of death in the distant past. Every single one of those “articulations” can be tested, probed and thereby multiplied. Entire bodies of thought can be built on different hypotheses about the corpse. So, Latour maintained, rather than those who assertively claim to know what actually happened 3,000 years ago, the journalist who declared vertiginously that Ramesses had (finally) died of TB in 1976 came closer to the truth in registering both the gulf that separates us from an event millennia in the past and the radical historical immanence of our current diagnosis. In his effort to shake us out of the complacent framework of certainty that modernity had created around us, counter-intuitive provocations of this kind were part of Latour’s method.

Unlike Ramesses’ cause of death, Bruno Latour’s was well mapped. In the 21st century, a cancer diagnosis has immediate and drastic implications. It enrols you as a patient in the machinery of the medical-industrial complex. Among all the hybrids that modern societies have created, the medical apparatus is one of the most complex. It grows ever larger and imposes its urgency in a relentless and merciless fashion. If you take your critical vantage point from an early 20th-century theorist of alienation, like Lukács or Weber for instance, it is tempting to think of this technoscientific medical apparatus as a steel-hard cage that relentlessly objectifies its patients, as bodies and cases. But for Latour, this again falls into a modernist trap. To start from the premise that objectification is actually achieved is to misunderstand and to grant too much. “Reductionism is not a sin for which scientists should make amends, but a dream precisely as unreachable as being alive and having no body. Even the hospital is not able to reduce the patient to a ‘mere object’.”

Rather than reducing us, modern medicalisation multiplies us. “When you enter into contact with hospitals, your ‘rich subjective personality’ is not reduced to a mere package of objective meat: on the contrary, you are now learning to be affected by masses of agencies hitherto unknown not only to you, but also to doctors, nurses, administration, biologists, researchers who add to your poor inarticulate body complete sets of new instruments.” The body becomes a site of a profuse multiplicity: “How can you contain so much diversity, so many cells, so many microbes, so many organs, all folded in such a way that ‘the many act as one’, as [Alfred North] Whitehead said? No subjectivity, no introspection, no native feeling can be any match for the fabulous proliferation of affects and effects that a body learns when being processed by a hospital… Far from being less, you become more.”

It’s a brave image. Perhaps it was one that sustained Latour as the cancer and the agencies deployed to fight it laid waste to his flesh. Not for nothing people describe the illness as a battle. Like a war, it can go on for years.

Latour liked military images. Perhaps because they better captured his vision of history, as mysterious, opaque, complex and contingent. Military history is one area of the modern world in which even the most high-minded analysts end up talking about tanks, bridges, rivers, Himars, Javelins and the fog of war. In the end, it is often for want of nails that battles are lost. The original French title of Latour’s famous book on the 19th-century French microbiologist Louis Pasteur – Pasteur: guerre et paix des microbes suivi de Irréductions – paid homage to Tolstoy. In the English translation that reference was lost. The Pasteurization of France (1988) replaces the French’s titles nod to War and Peace with ugly sociologese.

Latour’s own life force was strong. In his apartment on Rue Danton, Paris, with the charred remains of Notre Dames in background, he shared wines with visitors from around the world from vineyards planted in response to climate change. Covid lockdowns left him impatient. As soon as global traffic resumed, in 2021 he was assisting in the curation of the Taipei biennial. Latour’s final book, After Lockdown: A Metamorphosis appeared in English in 2021. It carries his voice into the present inviting us to imagine ourselves in an inversion of Kafka’s fable, as happy termites emerging from the lockdown on six hairy legs. “With your antennae, your articulations, your emanations, your waste matter, your mandibles, your prostheses, you may at last be becoming a human being!” No longer ill at ease, “Nothing is alien to you anymore; you’re no longer alone; you quietly digest a few molecules of whatever reaches your intestines, after having passed through the metabolism of hundreds of millions of relatives, allies, compatriots and competitors.”

As he aged, Latour became more, not less radical. Often dismissed on the left for his scepticism about classical critical social theory, the ecological turn made Latour into nothing less than an eco-warrior. His cause was the overturning of the dream world that systematically failed to recognise or grasp the forces unleashed by the modernist apparatus of production and cognition. We needed to come down to Earth, to land. Only then could we begin the hard work, with other actors, of arriving at a sustainable modus vivendi. The urgency was that of war and his mobilisation was total. The range of projects that he spawned in recent decades – artistic, political, intellectual – was dizzying. All of them aimed to find new political forms, new parliaments, new articulations.

Unlike many commentators and politicians, in response to populism, and specifically the gilet jaunes protests of 2018, Latour did not retreat to higher levels of technocracy, but instigated a collective project to compile cahiers de doléance – books of complaint – like those assembled before the French Revolution of 1789. The aim was to enrol people from all walks of life in defining what they need to live and what threatened their livelihood.

Part of the project involved an interactive theatrical exercise enacted by Latour with the architect and performance-art impresario Soheil Hajmirbaba. In a kind of ritual game, the participants arranged themselves and the forces enabling and threatening their lives – ranging from sea level rise to the increased prices for diesel – on a circular stage marked out with a compass. It was, as Latour described it, “like a children’s game, light-hearted and a lot of fun. And yet, when you get near the middle, everyone gets a bit nervous… The centre of the crucible, where I timidly put my feet, is the exact intersection of a trajectory – and I’m not in the habit of thinking of myself as a vector of a trajectory – which goes from the past, all that I’ve benefited from so as to exist, to grow, sometimes without even realising it, on which I unconsciously count and which may well stop with me, through my fault, which won’t go towards the future anymore, because of all that threatens my conditions of existence, of which I was also unaware.”

“The amazing result of this little enactment,” he continued, “is that you’re soon surrounded by a small assembly, which nonetheless represents your most personal situation, in front of the other participants. The more attachments you list, the more clearly you are defined. The more precise the description, the more the stage fills up!… A woman in the group sums it up in one phrase: ‘I’m repopulated!’”

Thus, Latour reinvented the role of the engaged French intellectual for the 21st century. And in doing so he forced the follow-on question. Was he perhaps the last of his kind? Who comes after him? As far as intellectual standing is concerned, Latour would have been impatient with the question. He was too preoccupied with new problems and projects, too enthused by the networks of collaborators, young and old whose work he drew on and that he helped to energise. But in a more general sense the question of succession haunted him. That, after all, is the most basic issue posed by the ecological crisis. What comes after us? What is our responsibility to the continuity of life?

In his effort to enact the motion of coming down to Earth, Latour faced the question head on. “With my feet on the consortium’s compass, I consult myself: in terms of my minuscule actions, do I enhance or do I stifle the lives of those I’ve benefited from till now?” Asking that question, never content with complacent or self-satisfied answers, during the night of 8-9 October 2022, Bruno Latour died aged 75 in Paris, of pancreatic cancer.

The controversy about the relationship between GM mosquitoes and the Zika virus outbreak in Brazil

 

Pandora’s box: how GM mosquitos could have caused Brazil’s microcephaly disaster (The Ecologist)

Oliver Tickell

1st February 2016

Aedes Aegypti mosquito feeding on human blood. Photo: James Gathany via jentavery on Flickr (CC BY).

Aedes Aegypti mosquito feeding on human blood. This is the species that transmits Zika, and that was genetically engineered by Oxitec using the piggyBac transposon. Photo: James Gathany via jentavery on Flickr (CC BY).

In Brazil’s microcephaly epidemic, one vital question remains unanswered: how did the Zika virus suddenly learn how to disrupt the development of human embryos? The answer may lie in a sequence of ‘jumping DNA’ used to engineer the virus’s mosquito vector – and released into the wild four years ago in the precise area of Brazil where the microcephaly crisis is most acute.

These ‘promiscuous’ transposons have found special favour with genetic engineers, whose goal is to create ‘universal’ systems for transferring genes into any and every species on earth. Almost none of the geneticists has considered the hazards involved.

Since August 2015, a large number of babies in Northeast Brazil have been born with very small heads, a condition known as microcephaly, and with other serious malformations. 4,180 suspected cases have been reported.

Epidemiologists have found a convincing correlation between the incidence of the natal deformities and maternal infections with the Zika virus, first discovered in Uganda’s Zika Valley in 1947, which normally produces non-serious illness.

The correlation has been evidenced through the geographical distrubution of Zika infections and the wave of deformities. Zika virus has also been detected in the amniotic fluids and other tissues of the affected babies and their mothers.

This latter finding was recently reported by AS Oliveira Melo et al in a scientific paperpublished in the journal Ultrasound in Obstetrics & Gynecology, which noted evidence of intra-uterine infection. They also warn:

“As with other intrauterine infections, it is possible that the reported cases of microcephaly represent only the more severely affected children and that newborns with less severe disease, affecting not only the brain but also other organs, have not yet been diagnosed.”

The Brazilian Health Minister, Marcelo Castro, says he has “100% certainty” that there is a link between Zika and microcephaly. His view is supported by the medical community worldwide, including by the US Center for Disease Control.

Oliveira Melo et al draw attention to a mystery that lies at the heart of the affair: “It is difficult to explain why there have been no fetal cases of Zika virus infection reported until now but this may be due to the underreporting of cases, possible early acquisition of immunity in endemic areas or due to the rarity of the disease until now.

“As genomic changes in the virus have been reported, the possibility of a new, more virulent, strain needs to be considered. Until more cases are diagnosed and histopathological proof is obtained, the possibility of other etiologies cannot be ruled out.”

And this is the key question: how – if indeed Zika really is the problem, as appears likely – did this relatively innocuous virus acquire the ability to produce these terrible malformations in unborn human babies?

Oxitec’s GM mosquitoes

An excellent article by Claire Bernish published last week on AntiMedia draws attention to an interesting aspect of the matter which has escaped mainstream media attention: the correlation between the incidence of Zika and the area of release of genetically modified Aedes aegypti mosquitos engineered for male insterility (see maps, above right).

The purpose of the release was to see if it controlled population of the mosquitos, which are the vector of Dengue fever, a potentially lethal disease. The same species also transmits the Zika virus.

The releases took in 2011 and 2012 in the Itaberaba suburb of the city of Juazeiro, Bahia, Northeast Brazil, about 500 km west of ther coastal city of Recife. The experiment was written up in July 2015 in the journal PLOS Neglected Tropical Diseases in a paper titled ‘Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes’ by Danilo O. Carvalho et al.

An initial ‘rangefinder of 30,000 GM mosquitos per week took place between 19th May and 29th June 2011, followed by a much larger release of 540,000 per week in early 2012, ending on 11th February.

At the end of it the scientists claimed “effective control of a wild population of Ae. aegypti by sustained releases of OX513A male Ae. aegypti. We diminished Ae. aegypti population by 95% (95% CI: 92.2%-97.5%) based on adult trap data and 78% (95% CI: 70.5%-84.8%) based on ovitrap indices compared to the adjacent no-release control area.”

So what’s to worry about?

    The idea of the Oxitec mosquitoes is simple enough: the males produce non-viable offspring which all die. So the GM mosqitoes are ‘self-extinguishing’ and the altered genes cannot survive in the wild population. All very clever, and nothing to worry about!

    But in fact, it’s not so simple. In 2010 geneticist Ricarda Steinbrecher wrote to the biosafety regulator in Malaysia – also considering a release of the Oxitec mosquitoes – with a number of safety concerns, pointing out the 2007 finding by Phuc et al that 3-4% of the first generation mosquitos actually survive.

    The genetic engineerig method employed by Oxitec allows the popular antibiotic tetracycline to be used to repress the lethality during breeding. But as a side-effect, the lethality is also reduced by the presence of tetracycline in the environment; and as Bernish points out, Brazil is among the world’s biggest users of anti-microbials including tetracycline in its commercial farming sector:

    “As a study by the American Society of Agronomy, et. al., explained, ‘It is estimated that approximately 75% of antibiotics are not absorbed by animals and are excreted in waste.’ One of the antibiotics (or antimicrobials) specifically named in that report for its environmental persistence is tetracycline.

    In fact, as a confidential internal Oxitec document divulged in 2012, that survival rate could be as high as 15% – even with low levels of tetracycline present. ‘Even small amounts of tetracycline can repress’ the engineered lethality. Indeed, that 15% survival rate was described by Oxitec.”

    She then quotes the leaked Oxitec paper: “After a lot of testing and comparing experimental design, it was found that [researchers] had used a cat food to feed the [OX513A] larvae and this cat food contained chicken. It is known that tetracycline is routinely used to prevent infections in chickens, especially in the cheap, mass produced, chicken used for animal food. The chicken is heat-treated before being used, but this does not remove all the tetracycline. This meant that a small amount of tetracycline was being added from the food to the larvae and repressing the [designed] lethal system.”

    So in other words, there is every possibility for Oxitec’s modified genes to persist in wild populations of Aedes aegypti mosquitos, especially in the environmental presence of tetracycline which is widely present in sewage, septic tanks, contaminated water sources and farm runoff.

    ‘Promiscuous’ jumping genes

    On the face of it, there is no obvious way in which the spread of Oxitec’s GM mosquitos into the wild could have anything to do with Brazil’s wave of micrcophaly. Is there?

    Actually, yes. The problem may arise from the use of the ‘transposon’ (‘jumping’ sequence of DNA used in the genetic engineering process to introduce the new genes into the target organism). There are several such DNA sequences in use, and one of the most popular is known as known as piggyBac.

    As a 2001 review article by Dr Mae Wan Ho shows, piggyBac is notoriously active, inserting itself into genes way beyond its intended target: “These ‘promiscuous’ transposons have found special favour with genetic engineers, whose goal is to create ‘universal’ systems for transferring genes into any and every species on earth. Almost none of the geneticists has considered the hazards involved …

    “It would seem obvious that integrated transposon vectors may easily jump out again, to another site in the same genome, or to the genome of unrelated species. There are already signs of that in the transposon, piggyBac, used in the GM bollworms to be released by the USDA this summer.

    The piggyBac transposon was discovered in cell cultures of the moth Trichopulsia, the cabbage looper, where it caused high rates of mutations in the baculovirus infecting the cells by jumping into its genes … This transposon was later found to be active in a wide range of species, including the fruitfly Drosophila, the mosquito transmitting yellow fever, Aedes aegypti, the medfly, Ceratitis capitata, and the original host, the cabbage looper.

    “The piggyBac vector gave high frequencies of transpositions, 37 times higher than mariner and nearly four times higher than Hirmar.”

    In a later 2014 report Dr Mae Wan Ho returned to the theme with additional detail and fresh scientific evidence (please refer to her original article for references): “The piggyBac transposon was discovered in cell cultures of the moth Trichopulsia, the cabbage looper, where it caused high rates of mutations in the baculovirus infecting the cells by jumping into its genes …

    “There is also evidence that the disabled piggyBac vector carrying the transgene, even when stripped down to the bare minimum of the border repeats, was nevertheless able to replicate and spread, because the transposase enzyme enabling the piggyBac inserts to move can be provided by transposons present in all genomes.

    “The main reason initially for using transposons as vectors in insect control was precisely because they can spread the transgenes rapidly by ‘non-Mendelian’ means within a population, i.e., by replicating copies and jumping into genomes, thereby ‘driving’ the trait through the insect population. However, the scientists involved neglected the fact that the transposons could also jump into the genomes of the mammalian hosts including human beings …

    “In spite of instability and resulting genotoxicity, the piggyBac transposon has been used extensively also in human gene therapy. Several human cell lines have been transformed, even primary human T cells using piggyBac. These findings leave us little doubt that the transposon-borne transgenes in the transgenic mosquito can transfer horizontally to human cells. The piggyBac transposon was found to induce genome wide insertionmutations disrupting many gene functions.” 

    Has the GM nightmare finally come true?

    So down to the key question: was the Oxitec’s GM Aedes aegypti male-sterile mosquito released in Juazeiro engineered with the piggyBac transposon? Yes, it was. And that creates a highly significant possibility: that Oxitec’s release of its GM mosquitos led directly to the development of Brazil’s microcephaly epidemic through the following mechanism:

    1. Many of the millions of Oxitec GM mosquitos released in Juazeiro in 2011/2012 survive, assisted, but not dependent on, the presence of tetracycline in the environment.

    2. These mosquitos interbreed with with the wild population and their novel genes become widespread.

    3. The promiscuous piggyBac transposon now present in the local Aedes aegyptipopulation takes the opportunity to jump into the Zika virus, probably on numerous occasions.

    4. In the process certain mutated strains of Zika acquire a selective advantage, making them more virulent and giving them an enhanced ability to enter and disrupt human DNA.

    5. One way in which this manifests is by disrupting a key stage in the development of human embryos in the womb, causing microcephaly and the other reported deformations. Note that as Melo Oliveira et al warn, there are almost certainly other manifestations that have not yet been detected.

    6. It may be that the piggyBac transposon has itself entered the DNA of babies exposed in utero to the modified Zika virus. Indeed, this may form part of the mechanism by which embryonic development is disrupted.

    In the latter case, one implication is that the action of the gene could be blocked by giving pregnant women tetracycline in order to block its activity. The chances of success are probably low, but it has to be worth trying.

    No further releases of GM insects!

    While I am certainly not claiming that this is what actually took place, it is at least a credible hypothesis, and moreover a highly testable one. Nothing would be easier for genetic engineers than to test amniotic fluids, babies’ blood, wild Aedes mosquitos and the Zika virus itself for the presence of the piggyBac transposon, using well established and highly sensitive PCR (polymerase chain reaction) techniques.

    If this proves to be the case, those urging caution on the release of GMOs generally, and transgenic insects bearing promiscuous transposons in particular, will have been proved right on all counts.

    But most important, such experiments, and any deployment of similar GM insects, must be immediately halted until the possibilities outlined above can be safely ruled out. There are plans, for example, to release similarly modified Anopheles mosquitos as an anti-malarial measure.

    There are also calls for even more of the Oxitec Aedes aegypti mosquitos to be released in order to halt the transmission of the Zika virus. If that were to take place, it could give rise to numerous new mutations of the virus with the potential to cause even more damage to the human genome, that we can, at this stage, only guess at.

    Oliver Tickell edits The Ecologist.


     

    No, GM Mosquitoes Didn’t Start The Zika Outbreak (Discovery)

    By Christie Wilcox | January 31, 2016 9:56 pm

    ZIka_conspiracy_theory_cat

    A new ridiculous rumor is spreading around the internets. According to conspiracy theorists, the recent outbreak of Zika can be blamed on the British biotech company Oxitec, which some are saying even intentionally caused the disease as a form of ethnic cleansing or population control. The articles all cite a lone Redditor who proposed the connection on January 25th to the Conspiracy subreddit. “There are no biological free lunches,” says one commenter on the idea. “Releasing genetically altered species into the environment could have disastrous consequences” another added. “Maybe that’s what some entities want to happen…?”

    For some reason, it’s been one of those months where random nonsense suddenly hits mainstream. Here are the facts: there’s no evidence whatsoever to support this conspiracy theory, or any of the other bizarre, anti-science claims that have popped up in the past few weeks. So let’s stop all of this right here, right now: The Earth is round, not flat (and it’s definitely not hollow). Last year was the hottest year on record, and climate change is really happening (so please just stop, Mr. Cruz). And FFS, genetically modified mosquitoes didn’t start the Zika outbreak. 

    Background on Zika

    The Zika virus is a flavivirus closely related to notorious pathogens including dengue, yellow fever, Japanese encephalitis, and West Nile virus. The virus is transmitted by mosquitoes in the genus Aedes, especially A. aegypti, which is a known vector for many of Zika’s relatives. Symptoms of the infection appear three to twelve days post bite. Most people are asymptomatic, which means they show no signs of infection. The vast majority of those who do show signs of infection report fever, rash, joint pain, and conjunctivitis (red eyes), according to the U.S. Centers for Disease Control. After a week or less, the symptoms tend to go away on their own. Serious complications have occurred, but they have been extremely rare.

    The Zika virus isn’t new. It was first isolated in 1947 from a Rhesus monkey in the Zika Forest in Uganda, hence the pathogen’s name. The first human cases were confirmed in Uganda and Tanzania in 1952, and by 1968, the virus had spread to Nigeria. But since then, the virus has found its way out of Africa. The first major outbreak occurred on the island of Yap in Micronesia for 13 weeks 2007, during which 185 Zika cases were suspected (49 of those were confirmed, with another 59 considered probable). Then, in October 2013, an outbreak began in French Polynesia; around 10,000 cases were reported, less than 100 of which presented with severe neurological or autoimmune complications. One confirmed case of autochthonous transmission occurred in Chile in 2014, which means a person was infected while they were in Chile rather than somewhere else. Cases were also reported that year from several Pacific Islands. The virus was detected in Chile until June 2014, but then it seemed to disappear.

    Fast forward to May 2015, when the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infection in Brazil. Since then, several thousand suspected cases of the disease and a previously unknown complication—a kind of birth defect known as microcephaly where the baby’s brain is abnormally small—have been reported from Brazil. (It’s important to note that while the connection between the virus and microcephaly is strongly suspected, the link has yet to be conclusively demonstrated.)

    Currently, there is no vaccine for Zika, though the recent rise in cases has spurred research efforts. Thus, preventing mosquito bites is the only prophylactic measure available.

    The recent spread of the virus has been described as “explosive”; Zika has now been detected in 25 countries and territories. The rising concern over both the number of cases and reports of serious complications has led the most affected areas in Brazil to declare a state of emergency, and on Monday, The World Health Organization’s Director-General will convene an International Health Regulations Emergency Committee on Zika virus and the observed increase in neurological disorders and neonatal malformations. At this emergency meeting, the committee will discuss mitigation strategies and decide whether the organization will officially declare the virus a “Public Health Emergency of International Concern.”

    GM to the Rescue

    aedes_aegypti

    The mosquito to blame for the outbreak—Aedes aegypti—doesn’t belong in the Americas. It’s native to Africa, and was only introduced in the new world when Europeans began to explore the globe. In the 20th century, mosquito control programs nearly eradicated the unwelcome menace from the Americas (largely thanks to the use of the controversial pesticide DDT); as late as the mid 1970s, Brazil and 15 other nations were Aedes aegypti-free. But despite the successes, eradication efforts were halted, allowing the mosquito to regain its lost territory.

    The distribution of Aedes aegypti in the Americas in 1970 and 2002.

    Effective control measures are expensive and difficult to maintain, so at the tail end of the 20th century and into the 21st, scientists began to explore creative means of controlling mosquito populations, including the use of genetic modification. Oxitec’s mosquitoes are one of the most exciting technologies to have emerged from this period. Here’s how they work, as I described in a post almost exactly a year ago:

    While these mosquitoes are genetically modified, they aren’t “cross-bred with the herpes simplex virus and E. colibacteria” (that would be an interkingdom ménage à trois!)—and no, they cannot be “used to bite people and essentially make them immune to dengue fever and chikungunya” (they aren’t carrying a vaccine!). The mosquitoes that Oxitec have designed are what scientists call “autocidal” or possess a “dominant lethal genetic system,” which is mostly fancy wording for “they die all by themselves”. The males carry inserted DNA which causes the mosquitoes to depend upon a dietary supplement that is easy to provide in the lab, but not available in nature. When the so-called mutants breed with normal females, all of the offspring require the missing dietary supplement because the suicide genes passed on from the males are genetically dominantThus, the offspring die before they can become adults. The idea is, if you release enough such males in an area, then the females won’t have a choice but to mate with them. That will mean there will be few to no successful offspring in the next generation, and the population is effectively controlled.

    Male mosquitoes don’t bite people, so they cannot serve as transmission vectors for Zika or any other disease. As for fears that GM females will take over: less than 5% of all offspring survive in the laboratory, and as Glen Slade, director of Oxitec’s Brazilian branch notes, those are the best possible conditions for survival. “It is considered unlikely that the survival rate is anywhere near that high in the harsher field conditions since offspring reaching adulthood will have been weakened by the self-limiting gene,” he told me. And contrary to what the conspiracy theorists claim, scientists have shown that tetracycline in the environment doesn’t increase that survival rate.

    Brazil, a hotspot for dengue and other such diseases, is one of the countries where Oxitec is testing their mozzies—so far, everywhere that Oxitec’s mosquitoes have been released, the local populations have been suppressed by about 90%.

    Wrong Place, Wrong Time

    Now that we’ve covered the background on the situation, let’s dig into the conspiracy theory. We’ll start with the main argument laid out as evidence: that the Zika outbreak began in the same location at the same time as the first Oxitec release:

    Though it’s often said, it’s worth repeating: correlation doesn’t equal causation. If it did, then Nicholas Cage is to blame for people drowning (Why, Nick? WHY?). But even beyond that, there are bigger problems with this supposed correlation: even by those maps, the site of release is on the fringe of the Zika hotspot, not the center of it. Just look at the two overlaid:

    The epicenter of the outbreak and the release clearly don’t line up—the epicenter is on the coast rather than inland where the map points. Furthermore, the first confirmed cases weren’t reported in that area, but in the town of Camaçari, Bahia, which is—unsurprisingly—on the coast and several hundred kilometers from the release site indicated.

    But perhaps more importantly, the location on the map isn’t where the mosquitoes were released. That map points to Juazeiro de Norte, Ceará, which is a solid 300 km away from Juazeiro, Bahia—the actual site of the mosquito trial. That location is even more on the edge of the Zika-affected area:

    1: Juaziero de Norte, the identified location in by conspiracy theorists. 2: Juaziero, the actual location of Oxitec's release trial, about 300 km away.

    The mistake was made initially by the Redditor who proposed the conspiracy theory and has been propagated through lazy journalistic practices by every proponent since. Here’s a quick tip: if you’re basing your conspiracy theory on location coincidence, it’s probably a good idea to actually get the location right.

    They’re also wrong about the date. According to the D.C. Clothesline:

    By July 2015, shortly after the GM mosquitoes were first released into the wild in Juazeiro, Brazil, Oxitec proudly announced they had “successfully controlled the Aedes aegypti mosquito that spreads dengue fever, chikungunya and zika virus, by reducing the target population by more than 90%.”

    However, GM mosquitoes weren’t first released in Juazeiro, Bahia (let alone Juazeiro de Norte, Ceará) in 2015. Instead, the announcement by Oxitec was of the published results of a trial that occurred in Juaziero between May 2011 and Sept 2012—a fact which is clearly stated in the methods and results of the paper that Oxitec was so excited to share.

    A new control effort employing Oxitec mosquitoes did begin in April 2015, but not in Juaziero, or any of the northeastern states of Brazil where the disease outbreak is occurring. As another press release from Oxitec states, the 2015 releases of their GM mosquitoes were in Piracicaba, São Paulo, Brazil:

    Following approval by Brazil’s National Biosafety Committee (CTNBio) for releases throughout the country, Piracicaba’s CECAP/Eldorado district became the world’s first municipality to partner directly with Oxitec and in April 2015 started releasing its self-limiting mosquitoes whose offspring do not survive. By the end of the calendar year, results had already indicated a reduction in wild mosquito larvae by 82%. Oxitec’s efficacy trials across Brazil, Panama and the Cayman Islands all resulted in a greater than 90% suppression of the wild Ae. aegypti mosquito population–an unprecedented level of control.

    Based on the positive results achieved to date, the ‘Friendly Aedes aegypti Project’ in CECAP/Eldorado district covering 5,000 people has been extended for another year. Additionally, Oxitec and Piracicaba have signed a letter of intent to expand the project to an area of 35,000-60,000 residents. This geographic region includes the city’s center and was chosen due to the large flow of people commuting between it and surrounding neighborhoods which may contribute to the spread of infestations and infections.

    Piracicaba mosquito control results

     

    Piracicaba, for the record, is more than 1300 miles away from the Zika epicenter:

    TKTK

    So not only did the conspiracy theorists get the location of the first Brazil release wrong, they either got the date wrong, too, or got the location of the 2015 releases really, really off. Either way, the central argument that the release of GM mosquitoes by Oxitec coincides with the first cases of Zika virus simply doesn’t hold up.

    Scientists Speak Out

    As this ludicrous conspiracy theory has spread, so, too, has the scientific opposition to it. “Frankly, I’m a little sick of this kind of anti-science platform,” said vector ecologist Tanjim Hossain from the University of Miami, when I asked him what he thought. “This kind of fear mongering is not only irresponsible, but may very well be downright harmful to vulnerable populations from a global health perspective.”

    Despite the specious allusions made by proponents of the conspiracy, this is still not Jurassic Park, says Hossain.

    “We have a problem where ZIKV is spreading rapidly and is widely suspected of causing serious health issues,” he continued. “How do we solve this problem? An Integrated Vector Management (IVM) approach is key. We need to use all available tools, old and new, to combat the problem. GM mosquitoes are a fairly new tool in our arsenal. The way I see it, they have the potential to quickly reduce a local population of vector mosquitoes to near zero, and thereby can also reduce the risk of disease transmission. This kind of strategy could be particularly useful in a disease outbreak ‘hotspot’ because you could hypothetically stop the disease in its tracks so to speak.”

    Other scientists have shared similar sentiments. Alex Perkins, a biological science professor at Notre Dame, told Business Insider that rather than causing the outbreak, GM mosquitoes might be our best chance to fight it. “It could very well be the case that genetically modified mosquitos could end up being one of the most important tools that we have to combat Zika,” Perkins said. “If anything, we should potentially be looking into using these more.”

    Brazilian authorities couldn’t be happier with the results so far, and are eager to continue to fight these deadly mosquitoes by any means they can. “The initial project in CECAP/Eldorado district clearly showed that the ‘friendly Aedes aegypti solution’ made a big difference for the inhabitants of the area, helping to protect them from the mosquito that transmits dengue, Zika and chikungunya,” said Pedro Mello, secretary of health in Piracicaba. He notes that during the 2014/2015 dengue season, before the trial there began, there were 133 cases of dengue. “In 2015/2016, after the beginning of the Friendly Aedes aegypti Project, we had only one case.”

    It’s long past time to stop villainizing Oxitec’s mosquitoes for crimes they didn’t commit. Claire BernishThe Daily MFailMirror and everyone else who has spread these baseless accusations: I’m talking to you. The original post was in the Conspiracy subreddit—what more of a red flag for “this is wildly inaccurate bullsh*t” do you need? (After all, if this is a legit source, where are your reports on the new hidden messages in the $100 bill? or why the Illuminati wants people to believe in aliens?). It’s well known that large-scale conspiracy theories are mathematically challenged. Don’t just post whatever crap is spewed on the internet because you know it’ll get you a few clicks. It’s dishonest, dangerous, and, frankly, deplorable to treat nonsense as possible truth just to prey upon your audience’s very real fears of an emerging disease. You, with your complete lack of integrity, are maggots feeding on the decay of modern journalism, and I mean that with no disrespect to maggots.